PH Connect

Which patients may present with PAH?

Once thought to be a disease of young women, PAH is now known to affect both genders and all age groups.1

Associate Professor Eugene Kotlyar

Patients on high risk to develop PAH

Associate Professor Eugene Kotlyar

70-80%

of PAH patients
are female2

iPAH mean age at diagnosis is

50-65 years2

3 out of 4

PAH patients are in WHO FC III-IV at the time of diagnosis3

Example cases* of patients presenting with PAH

*Examples for illustrative purposes only. Not based on actual patients.
"I’ve always been quite fit, but the last few months I’ve been getting more and more breathless when I do my morning walk. Sometimes I also feel dizzy, and exhausted for no reason.”
Laura, 46 Click here for more information
about advanced symptoms of PAH.
Laura, 46
“At first when I started feeling breathless, I thought it was just old age catching up with me. Then it started happening even when I was just sitting and watching TV. When I fainted in the kitchen, my wife insisted I go to the hospital.”
Geoff, 72Click here for more information
about advanced symptoms of PAH.
Geoff, 72
I was diagnosed with systemic sclerosis in my early 40s, so I’ve been dealing with that for a long time. A few months ago, I started feeling breathless, which worried me. Sometimes it also feels like my heart is beating very fast. My GP has done a few tests but isn’t sure what’s wrong.”
Harriet, 57Click here for more information
about advanced symptoms of PAH.
Harriet, 57
“I used to be quite active growing up and throughout my teens, so I really noticed it when I started feeling breathless while just walking around, and even feeling like I was going to faint! My GP was sure it was asthma, but I never had that as a child and the inhalers didn’t help at all.”
Lindsay, 20Click here for more information
about advanced symptoms of PAH.
Lindsay, 20
Previous
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Remember, if you see unexplained breathlessness similar to the cases above, Suspect PH.
References
  1. McGoon MD, et al. J Am Coll Cardiol 2013; 62(25 Suppl):D51-5.
  2. Hoeper MM and Gibbs JSR. Eur Respir Rev 2014; 23:450–7.
  3. Humbert M, et al. Am J Respir Crit Care Med 2006; 173:1023–30.
  4. McLaughlin VV, et al. J Am Coll Cadiol 2009; 53:1573–619.
Footnotes
FC=functional class; iPAH=idiopathic PAH; PAH=pulmonary arterial hypertension; SSc=systemic sclerosis; WHO=World Health Organization.

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Janssen-Cilag Pty Ltd, is proud to be a partner of PHSANZ in supporting education & research in the pulmonary hypertension field. PHSANZ is the professional society focused on facilitating research and educating members on the diagnosis and treatment of pulmonary hypertension. Their members include respiratory physicians, cardiologists, rheumatologists, immunologists, nurses and allied health professionals. If you would like more information about PHSANZ, please visit their site on this link.

Janssen is committed to monitoring the safety of our products.  We encourage healthcare professionals to report any suspected adverse events and product complaints for our products to Janssen Medical Information on 1800 226 334 and/or the TGA (at http://www.tga.gov.au/safety/problem-medicine.htm).

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Janssen-Cilag Pty Ltd
ACN 000 129 975. 1-5 Khartoum Rd Macquarie Park NSW 2113, Australia. Telephone: 1800 226 334 www.janssen.com/australia
Date of Prep: September 2020 CP-140515
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World Health Organization functional class (WHO-FC) for patients with PH3,5

This system grades PH severity according to the patient’s functional status, by linking symptoms with activity limitations. WHO-FC remains a powerful predictor of outcomes in patients with PAH.

WHO - FC Description
I
Patients with PH in whom there is no limitation of usual physical activity; ordinary physical activity does not cause increased dyspnoea, fatigue, chest pain, or presyncope.
II
Patients with PH who have mild limitation of physical activity. There is no discomfort at rest, but normal physical activity causes increased dyspnoea, fatigue, chest pain, or presyncope.
III
Patients with PH who have a marked limitation of physical activity. There is no discomfort at rest, but less than ordinary activity causes increased dyspnoea, fatigue, chest pain, or presyncope.
IV
Patients with PH who are unable to perform any physical activity at rest and who may have signs of right ventricular failure. Dyspnoea and/or fatigue may be present at rest, and symptoms are increased by almost any physical activity.
Adapted from McGoon M, et al. 2004.5
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